Plants send small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes

作者：Qiang Cai, Lulu Qiao, Ming Wang, Baoye He, Feng‐Mao Lin, Jared Palmquist, Sienna-Da Huang, Hailing Jin · 发表于：Science · 年份：2018 · DOI：10.1126/science.aar4142 · 被引用次数：1303 · 研究领域：Plant and Fungal Interactions Research、Plant Reproductive Biology、Plant pathogens and resistance mechanisms

Defense cargo shuttles in vesicles Plants can use small RNAs (sRNAs) to interfere with virulence factor gene expression in pathogens. Cai et al. show that the small mustard plant Arabidopsis shuttles defensive sRNAs into the necrotrophic fungus Botrytis cinerea via extracellular vesicles (see the Perspective by Thomma and Cook). The vesicles are associated with tetraspanin proteins, which can interact and form membrane microdomains. Several dozen different sRNAs targeting the pathogenic process were transported from Arabidopsis to B. cinerea in a selective manner. Science , this issue p. 1126 ; see also p. 1070