MMP1/PAR1/SP/NK1R paracrine loop modulates early perineural invasion of pancreatic cancer cells

作者：Chumei Huang, Yaqing Li, Yubo Guo, Z. Zhang, Guoda Lian, Yinting Chen, Jian Li, Yonghui Su, Jiajia Li, Kege Yang, Shaojie Chen, Hong Su, Kaihong Huang, Linjuan Zeng · 发表于：Theranostics · 年份：2018 · DOI：10.7150/thno.24281 · 被引用次数：107 · 研究领域：Pancreatic and Hepatic Oncology Research、Cancer, Stress, Anesthesia, and Immune Response、Neuropeptides and Animal Physiology

In this study, we provided evidence that the MMP1/PAR1/SP/NK1R paracrine loop contributes to PNI during the early stage of primary tumor formation. Furthermore, we established a sensitive and non-invasive method to detect nerve invasion using iron oxide nanoparticles and MRI.