Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism

作者：Ying Yang, Ying Yang, Phillip J. Hsu, Yu-Sheng Chen, Yun‐Gui Yang, Yun‐Gui Yang · 发表于：Cell Research · 年份：2018 · DOI：10.1038/s41422-018-0040-8 · 被引用次数：1818 · 研究领域：RNA modifications and cancer、RNA Research and Splicing、HVDC Systems and Fault Protection

Abstract N 6 -methyladenosine (m 6 A) is a chemical modification present in multiple RNA species, being most abundant in mRNAs. Studies on enzymes or factors that catalyze, recognize, and remove m 6 A have revealed its comprehensive roles in almost every aspect of mRNA metabolism, as well as in a variety of physiological processes. This review describes the current understanding of the m 6 A modification, particularly the functions of its writers, erasers, readers in RNA metabolism, with an emphasis on its role in regulating the isoform dosage of mRNAs.