Relationship between Serum Soluble Klotho Protein and Coronary Artery Calcification and Prognosis in Patients on Maintenance Hemodialysis.

作者：Shubei Zheng, Yu Zheng, Lingwei Jin, Zhihong Zhou, Zhanyuan Li · 发表于：PubMed · 年份：2018 · 被引用次数：22 · 研究领域：Parathyroid Disorders and Treatments、Dialysis and Renal Disease Management、Thyroid and Parathyroid Surgery

BACKGROUND: We aimed to investigate the relationship between serum soluble Klotho protein (sKlotho) level and coronary artery calcification (CAC) as well as prognosis in patients with maintenance hemodialysis (MHD). METHODS: Overall, 128 adult patients with end-stage renal failure treated with MHD were collected in the Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Zhejiang Province, China in 2013. Serum sKlotho was detected by ELISA and coronary artery calcification was measured by multi-slice spiral computed tomography (MSCT). With 36 months' follow-up, death notes such as cause of death and death time were recorded. RESULTS: <0.05). CONCLUSION: SKlotho can increase the degree of CAC. Although MHD patients with low sKlotho level had shorter survival time, sKlotho is not an independent risk factor in prediction of prognosis of MHD patients.