Expression and clinical significance of KiSS-1 and E-cadherin in gastric cardia adenocarcinoma

作者：Lidong Wang, Xiao Feng, Zhan Hui Wang, Gong Ping Wang, She Gan Gao, Jiang Tao Sun, Jian Qiang Mi, Tan You Shan, Zhi Qu, Jing Han, Luo Zhang · 发表于：Cancer Research · 年份：2007 · 研究领域：Cancer-related gene regulation、Peptidase Inhibition and Analysis、Glycosylation and Glycoproteins Research

5450 To investigate the expression and clinical significance of KiSS -1 and E-cadherin in gastric cardia adenocarcinoma (GCA), the present study was undertaken to characterize the changes of KiSS-1 and E-cadherin in protein level on the subjects with normal gastric cardia epithelia (n = 20) and GCA (n = 80). The Streptavidin Peroxidase (SP) method was performed to determine the expression of KiSS-1 and E-cadherin. Of the 80 surgical resected GCA specimen, there were 48 subjects with lymph node metastasis. Immunohistochemistry results showed that the positive immunostaining rates for KiSS-1 and E-cadherin were 65% (13/20) and 80% (16/20) in normal gastric cardia epithelia, and 36% (29/80) and 40% (32/80) in GCA, respectively. The difference was significant (P