Mesenchymal stem cells: potential application for the treatment of hepatic cirrhosis

作者：Yongting Zhang, Yuwen Li, Lili Zhang, Jun Li, Chuanlong Zhu · 发表于：Stem Cell Research & Therapy · 年份：2018 · DOI：10.1186/s13287-018-0814-4 · 被引用次数：60 · 研究领域：Organ Transplantation Techniques and Outcomes、Liver physiology and pathology、Mesenchymal stem cell research

Nowadays, orthotopic liver transplantation is considered the most efficient approach to the end stage of chronic hepatic cirrhosis. Because of the limitations of orthotopic liver transplantation, stem cells are an attractive therapeutic option. Mesenchymal stem cells (MSCs) especially show promise as an alternative treatment for hepatic cirrhosis in animal models and during clinical trials. Nevertheless, the homing of transplanted MSCs to the liver occurs in limited numbers. Therefore, we review the strategies for enhancing the homing of MSCs, mainly via the delivery routes, optimizing cell culture conditions, stimulating the target sites, and genetic modification.