Evaluation of the clinical application of multiple tumor marker protein chip in the diagnostic of lung cancer

作者：Xiao‐Chuan Wang, Yi Zhang, Sun Liangqi, Shuaiping Wang, Jing Nie, Wenqing Zhao, Guobao Zheng · 发表于：Journal of Clinical Laboratory Analysis · 年份：2018 · DOI：10.1002/jcla.22565 · 被引用次数：28 · 研究领域：Advanced Biosensing Techniques and Applications、Biosensors and Analytical Detection、Advanced Proteomics Techniques and Applications

BACKGROUND: The early diagnostic of lung cancer plays an important role in the prognosis of surgical treatment among lung cancer patients. To evaluate the clinical application of multi-tumor markers protein biochip in the diagnosis of lung cancer, 12 tumor markers were detected in patients with different stages of lung cancer. METHODS: Serum CA125, CA19-9, Ferritin, CA15-3, CA242, CEA, AFP, NSE, PSA, f-PSA, HGH, and β-HGH were assessed in 506 patients, with 224 patients with lung cancer (including 123 cases of adenocarcinoma, 30 squamous cell carcinoma, 54 small-cell carcinoma, and 17 non classification), 159 patients with benign lung disease and 90 healthy people control by the C-12 multiple tumor protein-chip detective system. RESULTS: The positive rate of C-12 (77.23%) in lung cancer was significantly higher than that of benign lung disease (13.84%) and healthy people (9.76%) (P < .01). In lung cancer, the positive rate of CA199, NSE, CEA, CA242, Ferritin, f-PSA, and CA125 were significantly higher than that of benign lung disease and healthy people. In adenocarcinoma, the positive rate of CA125 (73.53%) was significantly higher than that of squamous cell carcinoma (36.67%) and small-cell carcinoma (56.62%). CONCLUSION: The C-12 multiple tumor protein-chip detective system has acceptable sensitivity in the diagnostic of lung cancer.