Estrogen receptor α contributes to T cell–mediated autoimmune inflammation by promoting T cell activation and proliferation

作者：Imran Mohammad, Inna Starskaia, Tamás Nagy, Jitao Guo, Emrah Yatkin, Kalervo Väänänen, Wendy T. Watford, Zhi Jane Chen · 发表于：Science Signaling · 年份：2018 · DOI：10.1126/scisignal.aap9415 · 被引用次数：174 · 研究领域：T-cell and B-cell Immunology、Cytokine Signaling Pathways and Interactions、Immune Cell Function and Interaction

, which encodes a critical transcription factor for the differentiation and function of regulatory T cells. Thus, these data demonstrate that ERα in T cells plays an important role in inflammation and suggest that ERα-targeted immunotherapies could be used to treat autoimmune disorders.