Surface Decorated Porphyrinic Nanoscale Metal–Organic Framework for Photodynamic Therapy

作者：Jing‐Lan Kan, Yuan Jiang, Anqi Xue, Yinghao Yu, Quanbo Wang, Yang Zhou, Yu‐Bin Dong · 发表于：Inorganic Chemistry · 年份：2018 · DOI：10.1021/acs.inorgchem.8b00384 · 被引用次数：90 · 研究领域：Nanoplatforms for cancer theranostics、Metal-Organic Frameworks: Synthesis and Applications、Porphyrin and Phthalocyanine Chemistry

Nanocrystallization of organic molecular photosensitizers (PSs) by means of NMOF platforms has been demonstrated to be a promising approach to build up highly efficient PDT therapeutics. We report herein a new UiO-66 type of NMOF-based PS (UiO-66-TPP-SH), which is generated from UiO-66 NMOF and S-ethylthiol ester monosubstituted metal free porphyrin (TPP-SH) via a facile postsynthetic approach under mild conditions. The obtained NMOF (size less than 150 nm) with surface-decorated porphyrinic PS can not only retain MOF crystallinity, structural feature, and size, but also exhibit highly efficient singlet oxygen generation. Compared to the interior-located porphyrinic NMOF, UiO-66-TPP-SH shows significantly higher photodynamic activity and more efficient PDT tumor treatment.