Diagnosis, monitoring and prevention of exposure-related non-communicable diseases in the living and working environment: DiMoPEx-project is designed to determine the impacts of environmental exposure on human health

作者：Lygia Therese Budnik, Balázs Ádám, María Albin, Barbara Banelli, Xaver Baur, Fiorella Belpoggi, Claudia Bolognesi, Karin Bröberg, Per Gustavsson, Thomas Göen, Axel Fischer, Dorota Jarosińska, Fabiana Manservisi, Richard J O’Kennedy, Johan Øvrevik, Elizabet Paunović, Beate R. Ritz, Paul T.J. Scheepers, Vivi Schlünssen, Heidi Schwarzenbach, Per Everhard Schwarze, Orla M. Sheils, Torben Sigsgaard, Karel F. A. Van Damme, Ludwine Casteleyn · 发表于：Journal of Occupational Medicine and Toxicology · 年份：2018 · DOI：10.1186/s12995-018-0186-9 · 被引用次数：50 · 研究领域：Air Quality and Health Impacts、Health, Environment, Cognitive Aging、Climate Change and Health Impacts

The WHO has ranked environmental hazardous exposures in the living and working environment among the top risk factors for chronic disease mortality. Worldwide, about 40 million people die each year from noncommunicable diseases (NCDs) including cancer, diabetes, and chronic cardiovascular, neurological and lung diseases. The exposure to ambient pollution in the living and working environment is exacerbated by individual susceptibilities and lifestyle-driven factors to produce complex and complicated NCD etiologies. Research addressing the links between environmental exposure and disease prevalence is key for prevention of the pandemic increase in NCD morbidity and mortality. However, the long latency, the chronic course of some diseases and the necessity to address cumulative exposures over very long periods does mean that it is often difficult to identify causal environmental exposures. EU-funded COST Action DiMoPEx is developing new concepts for a better understanding of health-environment (including gene-environment) interactions in the etiology of NCDs. The overarching idea is to teach and train scientists and physicians to learn how to include efficient and valid exposure assessments in their research and in their clinical practice in current and future cooperative projects. DiMoPEx partners have identified some of the emerging research needs, which include the lack of evidence-based exposure data and the need for human-equivalent animal models mirroring human lifespan a...