Regulatory and Mechanistic Actions of Glucocorticoids on T and Inflammatory Cells

作者：Ana C. Liberman, Maia Ludmila Budziñski, Clara Sokn, Romina P. Gobbini, Anja Steininger, Eduardo Arzt · 发表于：Frontiers in Endocrinology · 年份：2018 · DOI：10.3389/fendo.2018.00235 · 被引用次数：183 · 研究领域：Estrogen and related hormone effects、Immune Response and Inflammation、Reproductive System and Pregnancy

Glucocorticoids (GCs) play an important role in regulating the inflammatory and immune response and have been used since decades to treat various inflammatory and autoimmune disorders. Fine-tuning the glucocorticoid receptor (GR) activity is instrumental in the search for novel therapeutic strategies aimed to reduce pathological signaling and restoring homeostasis. Despite the primary anti-inflammatory actions of GCs, there are studies suggesting that under certain conditions GCs may also exert pro-inflammatory responses. For these reasons the understanding of the GR basic mechanisms of action on different immune cells in the periphery (e.g., macrophages, dendritic cells, neutrophils, and T cells) and in the brain (microglia) contexts, that we review in this chapter, is a continuous matter of interest and may reveal novel therapeutic targets for the treatment of immune and inflammatory response.