Ruthenium-Catalyzed Decarboxylative C–H Alkenylation in Aqueous Media: Synthesis of Tetrahydropyridoindoles

作者：Xiaoyang Jin, Li‐Jun Xie, Hou‐Ping Cheng, An‐Di Liu, Xuedong Li, Dong Wang, Liang Cheng, Li Liu · 发表于：The Journal of Organic Chemistry · 年份：2018 · DOI：10.1021/acs.joc.8b00229 · 被引用次数：25 · 研究领域：Catalytic C–H Functionalization Methods、Catalytic Cross-Coupling Reactions、Synthesis and Catalytic Reactions

We disclose herein a Ru(II)-catalyzed decarboxylative and oxidative coupling of N-substituted indolyl carboxylic acids with broad substrate scope in an aqueous solution. This method provides a sustainable and efficient access to synthesize various indole-fused cyclohexanyl acetic acids under mild conditions.