Prevalence and risk factors for vascular calcification in Chinese patients receiving dialysis: baseline results from a prospective cohort study

作者：Zhi-Hong Liu, Xueqing Yu, Junwei Yang, Aili Jiang, Bi‐Cheng Liu, Changying Xing, Jizhuang Lou, Mei Wang, Hong Cheng, Jun Liu, Junzhou Fu, Aihua Zhang, Miao Zhang, Qiaoling Zhou, Chen Yu, Rong Wang, Li Wang, Yuqing Chen, Tianjun Guan, Ai Peng, Nan Chen, Chuan‐Ming Hao, Xu-Yang Cheng, for the China Dialysis Calcification Study Group · 发表于：Current Medical Research and Opinion · 年份：2018 · DOI：10.1080/03007995.2018.1467886 · 被引用次数：71 · 研究领域：Parathyroid Disorders and Treatments、Cardiac Imaging and Diagnostics、Gout, Hyperuricemia, Uric Acid

OBJECTIVE: With limited data available on calcification prevalence in chronic kidney disease (CKD) patients on dialysis, the China Dialysis Calcification Study (CDCS) determined the prevalence of vascular/valvular calcification (VC) and association of risk factors in Chinese patients with prevalent hemodialysis (HD) or peritoneal dialysis (PD). METHODS: CKD patients undergoing HD/PD for ≥6 months were enrolled. Prevalence data for calcification and medical history were documented at baseline. Coronary artery calcification (CAC) was assessed by electron beam or multi-slice computed tomography (EBCT/MSCT), abdominal aortic calcification (AAC) by lateral lumbar radiography, and cardiac valvular calcification (ValvC) by echocardiography. Serum phosphorus, calcium, intact parathyroid hormone (iPTH), and 25-hydroxyvitamin D and FGF-23 were evaluated. A logistic regression model was used to evaluate the association between risk factors and VC. RESULTS: Of 1,497 patients, 1,493 (78.3% HD, 21.7% PD) had ≥1 baseline calcification image (final analysis cohort, FAC) and 1,423 (78.8% HD, 21.2% PD) had baseline calcification data complete (BCDC). Prevalence of VC was 77.4% in FAC (80.8% HD, 65.1% PD, p < .001) and 77.5% in BCDC (80.7% HD, 65.8% PD). The proportion of BCDC patients with single-site calcification were 20% for CAC, 4.3% for AAC, and 4.3% for cardiac valvular calcification (ValvC), respectively. Double site calcifications were 23.4% for CAC and AAC, 6.5% for CAC and ValvC, and...