Biomarkers of Sepsis-Induced Acute Kidney Injury

作者：Kaifei Wang, Sheling Xie, Kun Xiao, Peng Yan, Wanxue He, Lixin Xie · 发表于：BioMed Research International · 年份：2018 · DOI：10.1155/2018/6937947 · 被引用次数：64 · 研究领域：Sepsis Diagnosis and Treatment、Acute Kidney Injury Research、Intensive Care Unit Cognitive Disorders

Sepsis, an infection-induced systemic disease, leads to pathological, physiological, and biochemical abnormalities in the body. Organ dysfunction is caused by a dysregulated host response to infection during sepsis which is a major contributing factor to acute kidney injury (AKI) and the mortality rate for sepsis doubles due to coincidence of AKI. Sepsis-induced AKI is strongly associated with increased mortality and other adverse outcomes. More timely diagnosis would allow for earlier intervention and could improve patient outcomes. Sepsis-induced AKI is characterized by a distinct pathophysiology compared with other diseases and may also have unique patterns of plasma and urinary biomarkers. This concise review summarizes properties and perspectives of the biomarkers for their individual clinical utilization.