Role of B-cell receptors for B-cell development and antigen-induced differentiation

作者：Juan Carlos Yam‐Puc, Lingling Zhang, Yang Zhang, Kai‐Michael Toellner · 发表于：F1000Research · 年份：2018 · DOI：10.12688/f1000research.13567.1 · 被引用次数：53 · 研究领域：T-cell and B-cell Immunology、Immune Cell Function and Interaction、Immunodeficiency and Autoimmune Disorders

B-cell development is characterized by a number of tightly regulated selection processes. Signals through the B-cell receptor (BCR) guide and are required for B-cell maturation, survival, and fate decision. Here, we review the role of the BCR during B-cell development, leading to the emergence of B1, marginal zone, and peripheral follicular B cells. Furthermore, we discuss BCR-derived signals on activated B cells that lead to germinal center and plasma cell differentiation.