Wall shear stress estimation in the aorta: Impact of wall motion, spatiotemporal resolution, and phase noise

作者：Judith Zimmermann, Daniel Demedts, Hanieh Mirzaee, Peter Ewert, Heiko Stern, Christian Meierhofer, Bjoern Menze, Anja Hennemuth · 发表于：Journal of Magnetic Resonance Imaging · 年份：2018 · DOI：10.1002/jmri.26007 · 被引用次数：31 · 研究领域：Coronary Interventions and Diagnostics、Cardiovascular Function and Risk Factors、Elasticity and Material Modeling

Background Wall shear stress (WSS) presents an important parameter for assessing blood flow characteristics and evaluating flow‐mediated lesions in the aorta. Purpose To investigate the robustness of WSS and oscillatory shear index (OSI) estimation based on 4D flow MRI against vessel wall motion, spatiotemporal resolution, and velocity encoding (VENC). Study Type Simulated and prospective. Population Synthetic 4D flow MRI data of the aorta, simulated using the Lattice‐Boltzmann method; in vivo 4D flow MRI data of the aorta from healthy volunteers ( n = 11) and patients with congenital heart defects ( n = 17). Field Strength/Sequence 1.5T; 4D flow MRI with PEAK‐GRAPPA acceleration and prospective electrocardiogram triggering. Assessment Predicated upon 3D cubic B‐splines interpolation of the image velocity field, WSS was estimated in mid‐systole, early‐diastole, and late‐diastole and OSI was derived. We assessed the impact of spatiotemporal resolution and phase noise, and compared results based on tracked—using deformable registration—and static vessel wall location. Statistical Tests Bland–Altman analysis to assess WSS/OSI differences; Hausdorff distance (HD) to assess wall motion; and Pearson's correlation coefficient (PCC) to assess correlation of HD with WSS. Results Synthetic data results show systematic over‐/underestimation of WSS when different spatial resolution (mean ± 1.96 SD up to –0.24 ± 0.40 N/m 2 and 0.5 ± 1.38 N/m 2 for 8‐fold and 27‐fold voxel size, respective...