Palladium-Catalyzed Domino Cyclization/Alkylation of Terminal Alkynes: Synthesis of Alkynyl-Functionalized Azaindoline Derivatives

作者：Xin‐Xing Wu, Anjia Liu, Shuai Xu, Junxia He, Wei Sun, Shufeng Chen · 发表于：Organic Letters · 年份：2018 · DOI：10.1021/acs.orglett.8b00106 · 被引用次数：40 · 研究领域：Catalytic C–H Functionalization Methods、Catalytic Alkyne Reactions、Catalytic Cross-Coupling Reactions

A novel palladium-catalyzed domino cyclization/alkylation of terminal alkynes was achieved for the synthesis of alkynyl-functionalized 3,3-disubstituted azaindoline derivatives under air atmosphere conditions. Various types of terminal alkynes, including aromatic alkynes, aliphatic alkynes, and ferrocene acetylene, can undergo the process successfully. The protocol provides a range of alkynyl-functionalized azaindoline scaffolds bearing a quarternary carbon center.