Females have the survival advantage in glioblastoma

作者：Quinn T. Ostrom, Joshua B. Rubin, Justin Durla Lathia, Michael E. Berens, Jill S. Barnholtz‐Sloan · 发表于：Neuro-Oncology · 年份：2018 · DOI：10.1093/neuonc/noy002 · 被引用次数：207 · 研究领域：Glioma Diagnosis and Treatment、Meningioma and schwannoma management、Brain Metastases and Treatment

Glioblastoma is the most common type of malignant brain tumor in the United States, with an average annual age-adjusted incidence rate (AAAIR) of 3.20/100000.1 These tumors are 60% more incident in males (AAAIR = 3.99/100000) than females (AAAIR = 2.52/100000).1 Previous analyses have demonstrated a significant association between female sex and improved survival,2 but this has not been systematically assessed within population-based datasets. This study was approved by the institutional review board at University Hospitals Cleveland Medical Center. Data were obtained from the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) program3 and from a multicenter study in Ohio (the Ohio Brain Tumor Study [OBTS])4 for glioblastoma cases in patients ≥18 years old and diagnosed in 2007 or later that received standard of care treatment (eg, surgery followed by concurrent chemoradiation). The SEER 18 includes 18 central cancer registries and represents ~28% of the US population. Ohio is not included within the SEER program. Thus, it is unlikely that individuals from Ohio would be included in both datasets. There were 5372 SEER cases and 228 OBTS cases. Analysis was performed using sex-specific Cox proportional hazards models adjusted for extent of resection (subtotal vs gross total), age at diagnosis, and Karnofsky performance status (KPS) (OBTS only). Postsurgical KPS was available for only 117 of 228 and was imputed using multivariate imputation by chained...