DNA Nanotechnology-Enabled Interfacial Engineering for Biosensor Development

作者：Dekai Ye, Xiaolei Zuo, Chunhai Fan · 发表于：Annual Review of Analytical Chemistry · 年份：2018 · DOI：10.1146/annurev-anchem-061417-010007 · 被引用次数：133 · 研究领域：Advanced biosensing and bioanalysis techniques、Biosensors and Analytical Detection、DNA and Nucleic Acid Chemistry

Biosensors represent biomimetic analytical tools for addressing increasing needs in medical diagnosis, environmental monitoring, security, and biodefense. Nevertheless, widespread real-world applications of biosensors remain challenging due to limitations of performance, including sensitivity, specificity, speed, and reproducibility. In this review, we present a DNA nanotechnology-enabled interfacial engineering approach for improving the performance of biosensors. We first introduce the main challenges of the biosensing interfaces, especially under the context of controlling the DNA interfacial assembly. We then summarize recent progress in DNA nanotechnology and efforts to harness DNA nanostructures to engineer various biological interfaces, with a particular focus on the use of framework nucleic acids. We also discuss the implementation of biosensors to detect physiologically relevant nucleic acids, proteins, small molecules, ions, and other biomarkers. This review highlights promising applications of DNA nanotechnology in interfacial engineering for biosensors and related areas.