p38α signaling in Langerhans cells promotes the development of IL-17–producing T cells and psoriasiform skin inflammation

作者：Tingting Zheng, Weiheng Zhao, Hongjin Li, Shuxiu Xiao, Ran Hu, Miaomiao Han, Heng Liu, Yeqiang Liu, Kinya Otsu, Xinguang Liu, Gonghua Huang · 发表于：Science Signaling · 年份：2018 · DOI：10.1126/scisignal.aao1685 · 被引用次数：30 · 研究领域：Psoriasis: Treatment and Pathogenesis、Immunotherapy and Immune Responses、T-cell and B-cell Immunology

T cells by increasing the abundance of IL-23 and IL-6, two cytokines that stimulate IL-17 secretion. Inhibition of p38 activity through either pharmacological inhibition or genetic deletion also reduced the severity of established psoriasiform skin inflammation. Together, our findings indicate a critical role for p38α signaling in LCs in promoting inflammatory responses in the skin and suggest that targeting p38α signaling in LCs may offer an effective therapeutic approach to treat psoriasis.