Ambient air pollution the risk of stillbirth: A prospective birth cohort study in Wuhan, China

作者：Shaoping Yang, Yafei Tan, Hui Mei, Fang Wang, Na Li, Jinzhu Zhao, Yiming Zhang, Zhengmin Qian, Jen Jen Chang, Kevin M. Syberg, Anna Peng, Hong Mei, Dan Zhang, Yan Zhang, Shunqing Xu, Yuanyuan Li, Tongzhang Zheng, Bin Zhang · 发表于：International Journal of Hygiene and Environmental Health · 年份：2018 · DOI：10.1016/j.ijheh.2018.01.014 · 被引用次数：109 · 研究领域：Air Quality and Health Impacts、Energy and Environment Impacts、Atmospheric chemistry and aerosols

Background Recent studies suggest that ambient air pollution exposure during pregnancy is associated with stillbirth occurrence. However, the results on the associations between ambient air pollutants and stillbirths are inconsistent and little is known about the gestational timing of sensitive periods for the effects of ambient air pollutants exposure on stillbirth. Objective This study aimed to examine whether exposure to high levels of ambient air pollutants in a Chinese population is associated with an increased risk of stillbirth, and determine the gestational period when the fetus is most susceptible. Methods We conducted a population-based cohort study in Wuhan, China, involving 95,354 births between June 10, 2011 and June 9, 2013. The exposure assessments were based on the daily mean concentrations of air pollutants obtained from the exposure monitor nearest to the pregnant women’s residence. Logistic regression analyses were performed to determine the associations between stillbirths and exposure to each of the air pollutants at different pregnancy periods with adjustment for confounding factors. Results Stillbirth increased with a 10 μg/m 3 increase in particulate matter 2.5 (PM 2.5 ) in each stage of pregnancy, and a significant association between carbon monoxide (CO) exposure and stillbirth was found during the third trimester (adjusted odds ratio (aOR): 1.01, 95% confidence interval (CI): 1.00–1.01) and in the entire pregnancy (aOR: 1.18, 95% CI: 1.04–1.34). Fur...