Deguelin exerts anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro

作者：Wen Kang, Zheng Xiao, Ping Wang, Shanyu Guo · 发表于：International Journal of Molecular Medicine · 年份：2018 · DOI：10.3892/ijmm.2018.3532 · 被引用次数：27 · 研究领域：Cancer-related Molecular Pathways、DNA Repair Mechanisms、Mitochondrial Function and Pathology

During the pathogenesis of gastric cancer, Akt signaling is considered as a pivotal inducer of gastric cancer development. Here we report the identification of anticancer activities of deguelin, a natural agent that inhibits Akt signaling. When applied to MGC-803 and MKN-45 cells, deguelin suppressed the proliferation and arrested cell cycle by p21-mediated inhibition of cyclin E. We further present in vitro evidence that deguelin promoted apoptosis of cancer cells by decreasing the phospho-Akt signaling and affecting expression of the apoptosis-associated genes Bax and Bcl-2. Additionally, deguelin was found to suppress the migration and invasion of gastric cancer cells. Taken together, these results indicated that deguelin exerted anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro.