Effects of oral contraceptives on ovulation induction in in vitro fertilization patients with premature ovarian insufficiency

作者：M. Chen, Hao J. Han, Yunhai Chuai, Ming Hao, Mingming Shu, W. Shang · 发表于：Climacteric · 年份：2018 · DOI：10.1080/13697137.2018.1439912 · 被引用次数：11 · 研究领域：Ovarian function and disorders、Reproductive Health and Contraception、Reproductive Health and Technologies

OBJECTIVE: To report a case series of in vitro fertilization patients with premature ovarian insufficiency, who were treated with oral contraceptives to reduce follicle stimulating hormone levels. METHOD: This was a consecutive case series in a tertiary teaching hospital in China. Twenty-two women with refractory and idiopathic premature ovarian insufficiency were administered a drospirenone/ethinylestradiol oral contraceptive orally. The main outcome measures were the number of oocytes retrieved and the number of embryos frozen. RESULTS: There were total 106 oral contraceptive treatment cycles and 53 oocyte retrieval cycles in 20 patients (91%, 20/22; 2.4 cycles per woman, 53/22). The total number of oocytes retrieved was 48 in 17 patients (77%, 17/22; 2.2 oocytes per woman, 48/22), and the total number of embryos frozen was 33 in 16 patients (73%, 16/22; 1.5 embryos per woman, 33/22). CONCLUSION: Oral contraception may be an effective method to induce ovulation for some patients with premature ovarian insufficiency.