Studies towards the Synthesis of the Antibiotic Tetrodecamycin

作者：Victor Lee, Jing He, Jack E. Baldwin · 发表于：Synlett · 年份：2018 · DOI：10.1055/s-0037-1609303 · 被引用次数：5 · 研究领域：Asymmetric Synthesis and Catalysis、Microbial Natural Products and Biosynthesis、Chemical synthesis and alkaloids

A study towards the natural product tetrodecamycin is reported. A modified Schlosser–Wittig reaction was utilized to prepare the precursor for the subsequent intramolecular Diels–Alder reaction, which delivered the trans-decalin ring of the natural product. The tetronic­ acid moiety of the molecule was prepared by a Dieckmann cyclization­. The cyclization of the tetronic acid to the trans-decalin double­ bond to form a seven-membered ring was examined.