Biomimetic mineralized strontium-doped hydroxyapatite on porous poly(L-lactic acid) scaffolds for bone defect repair

作者：Min Ge, Kun Ge, Fei Gao, Weixiao Yan, Huifang Liu, Xue Li, Yi Jin, Haiyun Ma, Jinchao Zhang · 发表于：International Journal of Nanomedicine · 年份：2018 · DOI：10.2147/ijn.s154605 · 被引用次数：101 · 研究领域：Bone Tissue Engineering Materials、biodegradable polymer synthesis and properties、Orthopaedic implants and arthroplasty

INTRODUCTION: poly(l-lactic acid) (PLLA) has been approved for clinical use by the US Food and Drug Administration (FDA); however, their stronger hydrophobicity and relatively fast degradation rate restricted their widespread application. In consideration of the composition of bone, the inorganic-organic composite has a great application prospect in bone tissue engineering. Many inorganic-organic composite scaffolds were prepared by directly mixing the active ingredient, but this method is uncontrolled and will lead to lack of homogeneity in the polymer matrix. Strontium (Sr) is an admirable addition to improve the bioactivity and bone induction of hydroxyapatite (HA). To our knowledge, the application of biomimetic mineralized strontium-doped hydroxyapatite on porous poly(l-lactic acid) (Sr-HA/PLLA) scaffolds for bone defect repair has never been reported till date. Biomimetic mineralized Sr-HA/PLLA porous scaffold was developed in this study. The results indicated that the Sr-HA/PLLA porous scaffold could improve the surface hydrophobicity, reduce the acidic environment of the degradation, and enhance the osteoinductivity; moreover, the ability of protein adsorption and the modulus of compression were increased. The results also clearly showed the effectiveness of the Sr-HA/PLLA porous scaffold in promoting cell adhesion, proliferation, and alkaline phosphatase (ALP) activity. The micro computed tomography (micro-CT) results showed that more new bones were formed by Sr-HA/P...