High Genetic Plasticity in Multidrug-Resistant Sequence Type 3-IncHI2 Plasmids Revealed by Sequence Comparison and Phylogenetic Analysis

作者：Liang‐Xing Fang, Xing‐Ping Li, Guo-Hui Deng, Shumin Li, Runshi Yang, Zuowei Wu, Xiao‐Ping Liao, Jian Sun, Ya-Hong Liu · 发表于：Antimicrobial Agents and Chemotherapy · 年份：2018 · DOI：10.1128/aac.02068-17 · 被引用次数：28 · 研究领域：Antibiotic Resistance in Bacteria、Enterobacteriaceae and Cronobacter Research、Bacteriophages and microbial interactions

ABSTRACT We report a novel fusion plasmid, pP2-3T, cointegrating sequence type 3 (ST3)-IncHI2 with an IncFII plasmid backbone mediating multidrug resistance (MDR) and virulence. Phylogenetic analysis and comparative genomics revealed that pP2-3T and other MDR ST3-IncHI2 plasmids clustered together, representing a unique IncHI2 lineage that exhibited high conservation in backbones of plasmids but possessed highly genetic plasticity in various regions by acquiring numerous antibiotic resistance genes and fusing with other plasmids. Surveillance studies should be performed to monitor multiresistance IncHI2 plasmids among Enterobacteriaceae .