Use of Mobile Devices to Measure Outcomes in Clinical Research, 2010–2016: A Systematic Literature Review

作者：Brian Perry, William G. Herrington, Jennifer C. Goldsack, Cheryl A. Grandinetti, Kaveeta P. Vasisht, Martin Landray, Lauren Bataille, Robert A. DiCicco, Corey Bradley, Ashish Narayan, Elektra J. Papadopoulos, Nirav Sheth, Ken Skodacek, Komathi Stem, Theresa V. Strong, Marc K. Walton, Amy L. Corneli · 发表于：Digital Biomarkers · 年份：2018 · DOI：10.1159/000486347 · 被引用次数：82 · 研究领域：Mobile Health and mHealth Applications、Physical Activity and Health、Digital Mental Health Interventions

BACKGROUND: The use of mobile devices in clinical research has advanced substantially in recent years due to the rapid pace of technology development. With an overall aim of informing the future use of mobile devices in interventional clinical research to measure primary outcomes, we conducted a systematic review of the use of and clinical outcomes measured by mobile devices (mobile outcomes) in observational and interventional clinical research. METHOD: We conducted a PubMed search using a range of search terms to retrieve peer-reviewed articles on clinical research published between January 2010 and May 2016 in which mobile devices were used to measure study outcomes. We screened each publication for specific inclusion and exclusion criteria. We then identified and qualitatively summarized the use of mobile outcome assessments in clinical research, including the type and design of the study, therapeutic focus, type of mobile device(s) used, and specific mobile outcomes reported. RESULTS: = 66) described observational clinical research. Thirteen therapeutic areas were represented. Five categories of mobile devices were identified: (1) inertial sensors, (2) biosensors, (3) pressure sensors and walkways, (4) medication adherence monitors, and (5) location monitors; inertial sensors/accelerometers were most common (reported in 86% of the publications). Among the variety of mobile outcomes, various assessments of physical activity were most common (reported in 74% of the publica...