Two new phenylspirodrimanes from the deep-sea derived fungus Stachybotrys sp. MCCC 3A00409

作者：Xinhua Ma, Weimin Zheng, Kai‐Hui Sun, Xiaofan Gu, Xianming Zeng, Haitao Zhang, Tian‐Hua Zhong, Zongze Shao, Yonghong Zhang · 发表于：Natural Product Research · 年份：2018 · DOI：10.1080/14786419.2018.1455041 · 被引用次数：24 · 研究领域：Microbial Natural Products and Biosynthesis、Marine Sponges and Natural Products、Fungal Biology and Applications

Two new phenylspirodrimanes, stachybotrin H (1) and stachybotrysin H (9) together with eleven known analogues (2–8, 10–13) were isolated from deep-sea derived Stachybotrys sp. MCCC 3A00409. Their structures were determined by extensive NMR data and mass spectroscopic analysis. Compounds 9–12 showed weak cytotoxicity against three human cancer cell lines K562, Hela and HL60 with IC50 in the range of 18.5–52.8 μM.