Highly Efficient Synthesis and Structure–Activity Relationships of a Small Library of Substituted 1,4‐Naphthoquinones

作者：Na Bao, Jinfeng Ou, Wei Shi, Na Li, Li Chen, Jianbo Sun · 发表于：European Journal of Organic Chemistry · 年份：2018 · DOI：10.1002/ejoc.201800207 · 被引用次数：17 · 研究领域：Bioactive Compounds and Antitumor Agents、Cancer therapeutics and mechanisms、Morinda citrifolia extract uses

A platform of highly efficient synthetic methodologies has been established to access a focused library of substituted 1,4‐naphthoquinones derivatives functionalized with a diversity of amino/hydroxy/alkyl groups. Furthermore, the structure–activity relationship deduced from antiproliferative activities and toxicities of this 1,4‐naphthoquinone library and intracellular reactive oxygen species (ROS) level detections might warrant future potential of plumbagin ( 2 ) and compound 13 as promising basic structures to develop novel anti‐cancer agents.