An Efficient Synthesis of 1′,7′,8′,9′‐Tetrahydrospiro[indoline‐3,4′‐pyrazolo[3,4‐ b ]quinoline]‐2,5′(6′ H )‐dione Derivatives in Aqueous Medium

作者：Guang‐Zhou Zhu, Lingli Gao, Qiuyu Yu, Yaqi Qin, Junhua Xi, Liangce Rong · 发表于：Journal of Heterocyclic Chemistry · 年份：2018 · DOI：10.1002/jhet.3111 · 被引用次数：13 · 研究领域：Multicomponent Synthesis of Heterocycles、Synthesis and biological activity、Synthesis and Biological Evaluation

An efficient and green reactions of isatins, 3‐amine‐1 H ‐pyrazole (5‐methyl‐1 H ‐pyrazol‐3‐amine) and 1,3‐diketone in aqueous medium for the synthesis of novel 1′,7′,8′,9′‐tetrahydrospiro[indoline‐3,4′‐pyrazolo[3,4‐ b ]quinoline]‐2,5′(6′ H )‐dione derivatives were reported in this research. The advantages of this reaction are simple operation, mild‐reaction conditions, wide scope substrate, high yields, and friendly environment. The products were confirmed by IR, 1 H NMR, 13 C NMR, and HRMS.