Aneuploidization under segmental allotetraploidy in rice and its phenotypic manifestation

作者：Ying Wu, Yue Sun, Shuai Sun, Li Guo, Jie Wang, Bin Wang, Xiuyun Lin, Meng Huang, Zhiyun Gong, Karen Sanguinet, Zhiwu Zhang, Liu B · 发表于：Theoretical and Applied Genetics · 年份：2018 · DOI：10.1007/s00122-018-3077-7 · 被引用次数：53 · 研究领域：Chromosomal and Genetic Variations、Plant Disease Resistance and Genetics、Genomics and Phylogenetic Studies

KEY MESSAGE: We report a repertoire of diverse aneuploids harbored by a newly synthesized segmental allotetraploid rice population with fully sequenced sub-genomes and demonstrate their retention features and phenotypic consequences. Aneuploidy, defined as unequal numbers of different chromosomes, is a large-effect genetic variant and may produce diverse cellular and organismal phenotypes. Polyploids are more permissive to chromosomal content imbalance than their diploid and haploid counterparts, and therefore, may enable more in-depth investigation of the phenotypic consequences of aneuploidy. Based on whole-genome resequencing, we identify that ca. 40% of the 312 selfed individual plants sampled from an early generation rice segmental allotetraploid population are constitutive aneuploids harboring 55 distinct aneuploid karyotypes. We document that gain of a chromosome is more prevalent than loss of a chromosome, and the 12 rice chromosomes have distinct tendencies to be in an aneuploid state. These properties of aneuploidy are constrained by multiple factors including the number of genes residing on the chromosome and predicted functional connectivity with other chromosomes. Two broad categories of aneuploidy-associated phenotypes are recognized: those shared by different aneuploids, and those associated with aneuploidy of a specific chromosome. A repertoire of diverse aneuploids in the context of a segmental allotetraploid rice genome with fully sequenced sub-genomes provi...