Intravoxel incoherent motion diffusion-weighted magnetic resonance imaging for predicting histological grade of hepatocellular carcinoma: Comparison with conventional diffusion-weighted imaging

作者：Shaocheng Zhu, Yuehua Liu, Yi Wei, Linlin Li, Shewei Dou, Tingyi Sun, Dapeng Shi · 发表于：World Journal of Gastroenterology · 年份：2018 · DOI：10.3748/wjg.v24.i8.929 · 被引用次数：40 · 研究领域：MRI in cancer diagnosis、Hepatocellular Carcinoma Treatment and Prognosis、Advanced Neuroimaging Techniques and Applications

AIM: To compare intravoxel incoherent motion (IVIM)-derived parameters with conventional diffusion-weighted imaging (DWI) parameters in predicting the histological grade of hepatocellular carcinoma (HCC) and to evaluate the correlation between the parameters and the histological grades. METHODS: ) were calculated by two radiologists. The IVIM and conventional DWI parameters were compared among the different grades by using analysis of variance (ANOVA) and the Kruskal-Wallis test. Receiver operating characteristic (ROC) analysis was performed to evaluate the diagnostic efficiency of distinguishing between low-grade (grade 1, G1) and high-grade (grades 2 and 3, G2 and G3) HCC. The correlation between the parameters and the histological grades was assessed by using the Spearman correlation test. Bland-Altman analysis was used to evaluate the reproducibility of the two radiologists' measurements. RESULTS: values, which indicated excellent inter-observer agreement in the measurements between the two observers. CONCLUSION: The IVIM-derived D and ADC values show better diagnostic performance in differentiating high-grade HCC from low-grade HCC, and there is a moderate to good correlation between the ADC and D values and the histological grades.