Influential factors on radiotherapy efficacy and prognosis in patients with secondary lymph node metastasis after esophagectomy of thoracic esophageal squamous cell carcinoma

作者：Shaobing Zhou, Xinwei Guo, Liang Gu, Shengjun Ji · 发表于：Cancer Management and Research · 年份：2018 · DOI：10.2147/cmar.s147324 · 被引用次数：8 · 研究领域：Inflammatory Biomarkers in Disease Prognosis、Esophageal Cancer Research and Treatment、Statistical Methods in Epidemiology

Background: The purpose of this study was to clarify whether pretreatment tumor burden-related index, including the gross tumor volume (GTV) of metastatic lymph nodes (V LN ) and maximum diameter of metastatic lymph nodes (D LN ), and inflammatory markers, consisting of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), are useful for assessing the therapeutic effects and prognosis with secondary lymph node metastasis (LNM) receiving chemoradiotherapy (CRT) or radiotherapy (RT) alone after resection of esophageal squamous cell carcinoma (ESCC). Patients and methods: A total of 119 patients with secondary LNM after resection of ESCC were recruited and received curative RT only or CRT. The enrolled patients were grouped according to the median values of NLR, PLR, V LN , and D LN . The relationship between the responsiveness to treatment and these markers was analyzed by logistic analysis. The Kaplan–Meier method and log-rank test were adopted to calculate and compare the overall survival (OS) rates with these markers. The Cox models were used to carry out multivariate analyses. Results: Univariate logistic regression analysis showed that the responses to treatment were highly associated with treatment method ( P =0.011), NLR ( P =0.000), PLR ( P =0.003), V LN ( P =0.000), and D LN ( P =0.000). Next, multivariate logistic regression analysis showed that therapeutic method (hazard ratio [HR]=1.225, P =0.032), NLR (HR=2.697, P =0.019), and V LN (HR=4.607,...