Soft, smart contact lenses with integrations of wireless circuits, glucose sensors, and displays

作者：Jihun Park, Joohee Kim, So-Yun Kim, Woon Hyung Cheong, Jiuk Jang, Young‐Geun Park, Kyungmin Na, Yun‐Tae Kim, Jun Hyuk Heo, Chang Young Lee, Jung Heon Lee, Franklin Bien, Jang‐Ung Park · 发表于：Science Advances · 年份：2018 · DOI：10.1126/sciadv.aap9841 · 被引用次数：670 · 研究领域：Advanced Sensor and Energy Harvesting Materials、Green IT and Sustainability、Gaze Tracking and Assistive Technology

Recent advances in wearable electronics combined with wireless communications are essential to the realization of medical applications through health monitoring technologies. For example, a smart contact lens, which is capable of monitoring the physiological information of the eye and tear fluid, could provide real-time, noninvasive medical diagnostics. However, previous reports concerning the smart contact lens have indicated that opaque and brittle components have been used to enable the operation of the electronic device, and this could block the user's vision and potentially damage the eye. In addition, the use of expensive and bulky equipment to measure signals from the contact lens sensors could interfere with the user's external activities. Thus, we report an unconventional approach for the fabrication of a soft, smart contact lens in which glucose sensors, wireless power transfer circuits, and display pixels to visualize sensing signals in real time are fully integrated using transparent and stretchable nanostructures. The integration of this display into the smart lens eliminates the need for additional, bulky measurement equipment. This soft, smart contact lens can be transparent, providing a clear view by matching the refractive indices of its locally patterned areas. The resulting soft, smart contact lens provides real-time, wireless operation, and there are in vivo tests to monitor the glucose concentration in tears (suitable for determining the fasting glucose l...