Resting-State Functional MRI: Everything That Nonexperts Have Always Wanted to Know

作者：Han Lv, Zhenchang Wang, Elizabeth Tong, Leanne M. Williams, Greg Zaharchuk, Michael Zeineh, Andrea Goldstein‐Piekarski, Tali M. Ball, Chengde Liao, Max Wintermark · 发表于：American Journal of Neuroradiology · 年份：2018 · DOI：10.3174/ajnr.a5527 · 被引用次数：577 · 研究领域：Functional Brain Connectivity Studies、Advanced MRI Techniques and Applications、Advanced Neuroimaging Techniques and Applications

Resting-state fMRI was first described by Biswal et al in 1995 and has since then been widely used in both healthy subjects and patients with various neurologic, neurosurgical, and psychiatric disorders. As opposed to paradigm- or task-based functional MR imaging, resting-state fMRI does not require subjects to perform any specific task. The low-frequency oscillations of the resting-state fMRI signal have been shown to relate to the spontaneous neural activity. There are many ways to analyze resting-state fMRI data. In this review article, we will briefly describe a few of these and highlight the advantages and limitations of each. This description is to facilitate the adoption and use of resting-state fMRI in the clinical setting, helping neuroradiologists become familiar with these techniques and applying them for the care of patients with neurologic and psychiatric diseases.