Nucleolar and spindle‐associated protein 1 is a tumor grade correlated prognosis marker for glioma patients

作者：Tao Zhu, Pan Xie, Yuanfeng Gao, Masha Huang, Xi Li, Wei Zhang, Hong‐Hao Zhou, Zhaoqian Liu · 发表于：CNS Neuroscience & Therapeutics · 年份：2018 · DOI：10.1111/cns.12803 · 被引用次数：32 · 研究领域：Microtubule and mitosis dynamics、Hippo pathway signaling and YAP/TAZ、Neurofibromatosis and Schwannoma Cases

AIMS: Despite therapeutic advances in glioma management including surgery, radiation, and chemotherapy, the improvement of patient outcome is far from satisfactory. Nucleolar and spindle-associated protein 1 (NUSAP1) is an important functional protein during mitosis, and its abnormal expression is implicated in progression of different types of tumors. However, the role of NUSAP1 in gliomas remains unclear. METHODS: NUSAP1 expression in gliomas with different grades was investigated based on GEO glioma datasets. Kaplan-Meier survival analysis was used to evaluate its prognostic significance. In vitro assays were also performed to evaluate effects of NUSAP1 on malignant phenotypes of glioma cells by silencing NUSAP1. RESULTS: NUSAP1 expression was correlated not only with glioma grade but also with prognosis of glioma patients. NUSAP1 depletion suppressed proliferation of U251 cells by inducing cell cycle arrest at G2/M phase and apoptosis. NUSAP1 depletion rendered U251 cells impaired migratory ability as well. CONCLUSION: NUSAP1 is a potential prognosis marker for glioma patients and therapeutic strategies targeting NUSAP1 might hold promise in improving glioma treatment.