Accelerated long-term forgetting in presymptomatic autosomal dominant Alzheimer's disease: a cross-sectional study

作者：Philip S.J. Weston, Jennifer M. Nicholas, Susie M. D. Henley, Yuying Liang, Kirsty Macpherson, Elizabeth Donnachie, Jonathan M. Schott, Martin N. Rossor, Sebastian James Crutch, Christopher Robert Butler, Adam Z. Zeman, Nick C. Fox · 发表于：The Lancet Neurology · 年份：2018 · DOI：10.1016/s1474-4422(17)30434-9 · 被引用次数：128 · 研究领域：Dementia and Cognitive Impairment Research、Memory and Neural Mechanisms、Memory Processes and Influences

BACKGROUND: Tests sensitive to presymptomatic changes in Alzheimer's disease could be valuable for clinical trials. Accelerated long-term forgetting-during which memory impairment becomes apparent over longer periods than usually assessed, despite normal performance on standard cognitive testing-has been identified in other temporal lobe disorders. We assessed whether accelerated long-term forgetting is a feature of presymptomatic autosomal dominant (familial) Alzheimer's disease, and whether there is an association between accelerated long-term forgetting and early subjective memory changes. METHODS: This was a cross-sectional study at the Dementia Research Centre, University College London (London, UK). Participants were recruited from a cohort of autosomal dominant Alzheimer's disease families already involved in research at University College London, and had to have a parent known to be affected by an autosomal dominant Alzheimer's disease mutation, and not report any current symptoms of cognitive decline. Accelerated long-term forgetting of three tasks (list, story, and figure recall) was assessed by comparing 7-day recall with initial learning and 30-min recall. 7-day recognition was also assessed. Subjective memory was assessed using the Everyday Memory Questionnaire. The primary outcome measure for each task was the proportion of material retained at 30 min that was recalled 7 days later (ie, 7-day recall divided by 30-min recall). We used linear regression to compare...