MUC16overexpression induced by gene mutations promotes lung cancer cell growth and invasion

作者：Madiha Kanwal, Xiaojie Ding, Xin Song, Guang‐Biao Zhou, Yi Cao · 发表于：Oncotarget · 年份：2018 · DOI：10.18632/oncotarget.24203 · 被引用次数：46 · 研究领域：Cancer Genomics and Diagnostics、RNA modifications and cancer、DNA Repair Mechanisms

// Madiha Kanwal 1, 2, * , Xiao-Jie Ding 1, * , Xin Song 3 , Guang-Biao Zhou 4 and Yi Cao 1 1 Laboratory of Molecular and Experimental Pathology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2 Kunming College of Life Sciences, University of Chinese Academy of Sciences, Kunming, China 3 Department of Cancer Biotherapy Center, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, China 4 State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China * These authors contributed equally to this work Correspondence to: Yi Cao, email: caoy@mail.kiz.ac.cn ( yicao1212@yahoo.de ) Keywords: air pollution-related lung cancer; MUC16 (CA125); gene mutation; CRISPR/Cas9 gene editing; biomarker Received: October 02, 2017      Accepted: December 04, 2017      Published: January 12, 2018 ABSTRACT Air pollution is one of the leading causes of lung cancer. Air pollution-related lung cancer is a deteriorating public health problem, particularly in developing countries. The MUC16 gene is one of the most frequently mutated genes in air pollution-related lung cancer. In the present study, MUC16 mRNA expression was increased in ~50% of air pollution-related lung cancer samples obtained from patients residing in air-polluted regions (Xuanwei and Fuyuan, Yunnan, China), and MUC16 mRNA levels were correlated...