The human IL-15 superagonist ALT-803 directs SIV-specific CD8+ T cells into B-cell follicles

作者：Gabriela M. Webb, Shengbin Li, Gwantwa Mwakalundwa, Joy M. Folkvord, Justin Greene, Jason S. Reed, Jeffery J. Stanton, Alfred W. Legasse, Theodore R. Hobbs, Lauren Martin, Byung Park, James B. Whitney, Emily K. Jeng, Hing C. Wong, Douglas F. Nixon, R. Brad Jones, Elizabeth Connick, Pamela J. Skinner, Jonah B. Sacha · 发表于：Blood Advances · 年份：2018 · DOI：10.1182/bloodadvances.2017012971 · 被引用次数：93 · 研究领域：Immune Cell Function and Interaction、T-cell and B-cell Immunology、Reproductive System and Pregnancy

T cells from the peripheral blood into B-cell follicles. In agreement with the increased trafficking of SIV-specific cytotoxic T cells to sites of cryptic viral replication, lymph nodes of elite controlling macaques contained fewer cells expressing SIV RNA or harboring SIV DNA post-ALT-803 treatment. These data establish ALT-803 as an immunotherapeutic for HIV and other chronic viral pathogens that evade host immunity by persisting in B-cell follicles.