Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells

作者：Veron Ramsuran, Vivek Naranbhai, Amir Horowitz, Qi Ying, Maureen P. Martin, Yuko Yuki, Xiaojiang Gao, Victoria E. Walker-Sperling, Gregory Q. Del Prete, Douglas K. Schneider, Jeffrey D. Lifson, Jacques Fellay, Steven G. Deeks, Jeffrey N. Martin, James J. Goedert, Steven M. Wolinsky, Nelson L. Michael, Gregory D. Kirk, Susan Buchbinder, David W. Haas, Thumbi Ndung’u, Philip Goulder, Peter Parham, Bruce D. Walker, Jonathan M. Carlson, Mary Carrington · 发表于：Science · 年份：2018 · DOI：10.1126/science.aam8825 · 被引用次数：153 · 研究领域：Immune Cell Function and Interaction、T-cell and B-cell Immunology、HIV Research and Treatment

Inhibiting natural killer cells in AIDS The human leukocyte antigen (HLA) gene complex varies enormously among individuals and helps explain individual variation in immunity to infectious diseases. Ramsuran et al. examined data from almost 10,000 HIV infections. Expression of the HLA-A and - B alleles was associated with higher viral load, reduced CD4 + T cell counts, and accelerated progression to AIDS. Higher levels of HLA-A expression increased expression of HLA-E , which blocks a specific receptor (NKG2A) on the immune cells that normally eliminate virus-infected cells. Thus, targeting NKG2A might provide a therapeutic avenue for HIV treatment. Science , this issue p. 86