Incidence, risk factors and treatment outcomes of drug extravasation in pediatric patients in China

作者：Yamin Yan, Mei Gong, Jia-Ling Chen, Dan Li, Tingting Xu, Huan Zou, LI Ai-qiu, Qiaoling Fan, Qunfeng Lu · 发表于：The Turkish Journal of Pediatrics · 年份：2017 · DOI：10.24953/turkjped.2017.02.008 · 被引用次数：25 · 研究领域：Chemotherapy-related skin toxicity、Methemoglobinemia and Tumor Lysis Syndrome、Cancer Treatment and Pharmacology

Yan YM, Gong M, Chen JL, Li D, Xu TT, Zou H, Li AQ, Fan QL, Lu QF. Incidence, risk factors and treatment outcomes of drug extravasation in pediatric patients in China. Turk J Pediatr 2017; 59: 162-168. Extravasation injury is a common phenomenon in hospitals. Failure to detect and treat extravasation injury can lead to irreversible local injuries, tissue necrosis and malfunction of the affected tissue. Until now, it is largely unknown about incidence, risk factors and treatment outcomes of extravasation in Chinese pediatric patients. The aim of this study is to explore the incidence, risk factors and summarize the characteristics and treatment outcomes of extravasation injuries resulting in drug extravasation among Chinese children in our hospital. The children undergoing infusion therapy (0-18 years) were enrolled in this study between December 2014 and June 2015 in Shanghai Children`s Hospital. The patients` information including age, gender, injection site, estimated volume of solution extravasated, patient symptoms, severity of extravasation injury, treatment methods, and outcomes was collected. Multivariate logistic regression was used to identify the independent risk factors for the development of extravasation. The incidence of extravasations in pediatric patients was 1.79% (18/1,004). The severity of extravasation was labeled with grade range from Grade 1 through Grade 4: 4 cases with Grade 1, 8 cases with Grade 2, 5 cases with Grade 3, and 1 case with Grade 4. The ri...