Nanozyme Decorated Metal–Organic Frameworks for Enhanced Photodynamic Therapy

作者：Yan Zhang, Faming Wang, Chaoqun Liu, Zhenzhen Wang, Lihua Kang, Yanyan Huang, Kai Dong, Jinsong Ren, Xiaogang Qu · 发表于：ACS Nano · 年份：2017 · DOI：10.1021/acsnano.7b07746 · 被引用次数：855 · 研究领域：Nanoplatforms for cancer theranostics、Advanced Nanomaterials in Catalysis、Advanced Photocatalysis Techniques

Metal–organic frameworks (MOFs) have been used for photodynamic therapy (PDT) of cancers by integrating photosensitizers, which cause cytotoxic effects on cancer cells by converting tumor oxygen into reactive singlet oxygen ( 1 O 2 ). However, the PDT efficiency of MOFs is severely limited by tumor hypoxia. Herein, by decorating platinum nanozymes on photosensitizer integrated MOFs, we report a simple yet versatile strategy for enhanced PDT. The platinum nanoparticles homogeneously immobilized on MOFs possess high stability and catalase-like activity. Thus, our nanoplatform can facilitate the formation of 1 O 2 in hypoxic tumor site via H 2 O 2 -activated evolvement of O 2, which can cause more serious damage to cancer cells. Our finding highlights that the composites of nanozymes and MOFs have the potential to serve as efficient agents for cancer therapy, which will open an avenue of nanozymes and MOFs toward biological applications.