Organic-Dye-Modified Upconversion Nanoparticle as a Multichannel Probe To Detect Cu 2+ in Living Cells

作者：Bin Gu, Minan Ye, Lina Nie, Fang Yuan, Zilong Wang, Xiao Zhang, Hua Zhang, Yi Zhou, Qichun Zhang · 发表于：ACS Applied Materials & Interfaces · 年份：2017 · DOI：10.1021/acsami.7b13351 · 被引用次数：57 · 研究领域：Luminescence Properties of Advanced Materials、bioluminescence and chemiluminescence research、Luminescence and Fluorescent Materials

The development of an inorganic–organic hybrid probe to more accurately detect ions in living systems is very challenging but highly desirable. Here we combined upconversion nanoparticles with the electrically active ferrocene group to detect Cu 2+ in living cells. The as-prepared probe displays three different signal changes in absorption, emission, and electrochemical behavior, respectively, during Cu 2+ ion detection. Moreover, this new probe has been demonstrated to show high stability and adaptability. In addition, bioimaging testing reveals that this probe is suitable for detecting and visualizing Cu 2+ in A549 cells with low cytotoxicity.