Viral discovery and diversity in trypanosomatid protozoa with a focus on relatives of the human parasite Leishmania

作者：Danyil Grybchuk, Natalia S. Akopyants, Alexei Yu. Kostygov, Aleksandras Konovalovas, Lon‐Fye Lye, Deborah E. Dobson, Haroun Zangger, Nicolas J. Fasel, Anzhelika Butenko, Alexander O. Frolov, Jan Votýpka, Claudia M. d’Avila-Levy, Pavel Kulich, Jana Moravcová, Pavel Plevka, Igor B. Rogozin, Saulius Serva, Julius Lukeš, Stephen M. Beverley, Vyacheslav Yurchenko · 发表于：Proceedings of the National Academy of Sciences · 年份：2017 · DOI：10.1073/pnas.1717806115 · 被引用次数：107 · 研究领域：Research on Leishmaniasis Studies、Trypanosoma species research and implications、Viral Infections and Vectors

Significance Largely overlooked, the viruses of protists have started to attract more attention. Several viruses of the family Totiviridae are currently implicated in the increased pathogenicity of parasitic protozoa such as Leishmania to vertebrate hosts. We conducted a broad survey of RNA viruses within trypanosomatids, one of the iconic groups of protists. These revealed several previously unidentified viral taxa including one designated “ Leishbunyaviridae ” and a highly divergent virus termed “Leptomonas pyrrhocoris ostravirus 1.” Our studies provide important information on the origins as well as the diversity and distribution of viruses within a group of protists related to the human parasite Leishmania .