Phosphoinositide conversion in endocytosis and the endolysosomal system

作者：Alexander Wallroth, Volker Haucke · 发表于：Journal of Biological Chemistry · 年份：2017 · DOI：10.1074/jbc.r117.000629 · 被引用次数：211 · 研究领域：Cellular transport and secretion、Calcium signaling and nucleotide metabolism、Lipid Membrane Structure and Behavior

Phosphoinositides (PIs) are phospholipids that perform crucial cell functions, ranging from cell migration and signaling to membrane trafficking, by serving as signposts of compartmental membrane identity. Although phosphatidylinositol 4,5-bisphosphate, 3-phosphate, and 3,5-bisphosphate are commonly considered as hallmarks of the plasma membrane, endosomes, and lysosomes, these compartments contain other functionally important PIs. Here, we review the roles of PIs in different compartments of the endolysosomal system in mammalian cells and discuss the mechanisms that spatiotemporally control PI conversion in endocytosis and endolysosomal membrane dynamics during endosome maturation and sorting. As defective PI conversion underlies human genetic diseases, including inherited myopathies, neurological disorders, and cancer, PI-converting enzymes represent potential targets for drug-based therapies.