Acute myeloid leukemia with t(4;12)(q12;p13): an aggressive disease with frequent involvement of PDGFRA and ETV6

作者：Jingyi Li, Jie Xu, Lynne V. Abruzzo, Guilin Tang, Shaoying Li, M. James You, Gary Lu, Elias Jabbour, Qi Deng, Carlos E. Bueso‐Ramos, L. Jeffrey Medeiros, C. Cameron Yin · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.23743 · 被引用次数：8 · 研究领域：Eosinophilic Disorders and Syndromes、Acute Myeloid Leukemia Research、Chronic Myeloid Leukemia Treatments

// Jingyi Li 1, 2, * , Jie Xu 1, * , Lynne V. Abruzzo 1, 3 , Guilin Tang 1 , Shaoying Li 1 , M. James You 1 , Gary Lu 1, 4 , Elias J. Jabbour 5 , Qi Deng 2 , Carlos E. Bueso-Ramos 1 , L. Jeffrey Medeiros 1 and C. Cameron Yin 1 1 Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 2 Department of Hematology, Tianjin First Center Hospital, Tianjin, China 3 Current address: Department of Pathology, The Ohio State University, College of Medicine, Columbus, OH, USA 4 Current address: Department of Biomedical Sciences, University of South Carolina School of Medicine, Greenville, SC, USA 5 Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA * These authors contributed equally to this work Correspondence to: C. Cameron Yin, email: cyin@mdanderson.org Keywords: acute myeloid leukemia; t(4;12)(q12;p13); PDGFRA; ETV6 Received: September 21, 2017      Accepted: October 13, 2017      Published: December 15, 2017 ABSTRACT We describe the clinical, morphologic, immunophenotypic and molecular genetic features of 15 cases of acute myeloid leukemia (AML) with t(4;12)(q12;p13). There were 9 men and 6 women, with a median age of 50 years (range, 17–76). Most patients had hypercellular bone marrow with a median blast count of 58% and multilineage dysplasia. Flow cytometry analysis showed myeloid lineage with blasts positive for CD13, CD33, CD34, CD38, CD11...