Signature of survival: a 18F-FDG PET based whole-liver radiomic analysis predicts survival after 90Y-TARE for hepatocellular carcinoma

作者：Paul Blanc‐Durand, Axel Van Der Gucht, Mario Jreige, Marie Nicod Lalonde, Marina Silva-Monteiro, John O. Prior, Alban Denys, Adrien Depeursinge, Niklaus Schaefer · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.23423 · 被引用次数：57 · 研究领域：Hepatocellular Carcinoma Treatment and Prognosis、Radiomics and Machine Learning in Medical Imaging、Cholangiocarcinoma and Gallbladder Cancer Studies

// Paul Blanc-Durand 1, * , Axel Van Der Gucht 1, * , Mario Jreige 1 , Marie Nicod-Lalonde 1 , Marina Silva-Monteiro 1 , John O. Prior 1 , Alban Denys 2 , Adrien Depeursinge 3, * and Niklaus Schaefer 1, * 1 Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland 2 Department of Radiology and Interventional Radiology, Lausanne University Hospital, Lausanne, Switzerland 3 Institute of Information Systems, University of Applied Sciences Western Switzerland [HES-SO], Sierre, Switzerland * These authors contributed equally to this work Correspondence to: Paul Blanc-Durand, email: paul.blancdurand@gmail.com Keywords: 18 F-FDG PET; TARE; radiomics; hepatocellular carcinoma; survival Received: June 15, 2017 Accepted: November 28, 2017 Published: December 19, 2017 ABSTRACT Purpose: To generate a predictive whole-liver radiomics scoring system for progression-free survival (PFS) and overall survival (OS) in patients undergoing transarterial radioembolization using Yttrium-90 ( 90 Y-TARE) for unresectable hepatocellular carcinoma (uHCC). Results: The generated pPET-RadScores were significantly correlated with survival for PFS (median of 11.4 mo [95% confidence interval CI: 6.3–16.5 mo] in low-risk group [PFS-pPET-RadScore < 0.09] vs. 4.0 mo [95% CI: 2.3–5.7 mo] in high-risk group [PFS-pPET-RadScore > 0.09]; P = 0.0004) and OS (median of 20.3 mo [95% CI: 5.7–35 mo] in low-risk group [OS-pPET-RadScore < 0.11] vs. 7.7 mo [95% CI: 6.0–9.5 mo...