Prevalence and determinants of rapid eye movement sleep behavior disorder in the general population

作者：José Haba‐Rubio, Birgit Frauscher, Pedro Marques‐Vidal, Jérôme Toriel, Nadia Tobback, Daniela Andries, Martin Preisig, Péter Vollenweider, Ronald B. Postuma, Raphaël Heinzer · 发表于：SLEEP · 年份：2017 · DOI：10.1093/sleep/zsx197 · 被引用次数：285 · 研究领域：Sleep and Wakefulness Research、Restless Legs Syndrome Research、Parkinson's Disease Mechanisms and Treatments

STUDY OBJECTIVES: Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia associated with neurodegenerative synucleinopathies. Its prevalence is largely unknown. This study determined the prevalence and characteristics of RBD in the general population using gold-standard polysomnography. METHODS: Full polysomnographic data from 1,997 participants (age = 59 ± 11.1 years, 53.6% women) participating in a population-based study (HypnoLaus, Lausanne, Switzerland) were collected. Sleep-related complaints and habits were investigated using various sleep measures including the Munich Parasomnia Screening (MUPS) questionnaire, which includes two questions evaluating complex motor behaviors suggestive of RBD. Full polysomnography was performed at home. For participants screening positive for RBD, muscle activity during REM sleep was quantified to diagnose RBD. RESULTS: Three hundred sixty-eight participants endorsed dream-enactment behavior on either of the two MUPS questions, and 21 fulfilled polysomnographic criteria for RBD, resulting in an estimated prevalence of 1.06% (95% CI = 0.61-1.50), with no difference between men and women. Compared with RBD- participants, RBD+ took more frequently antidepressants and antipsychotics (23.8% vs. 5.4%, p = .005; 14.3% vs. 1.5%, p = .004, respectively) and were more frequently smokers or ex-smokers (85% vs. 56.6%, p = .011). On polysomnography, RBD+ had more stage N2 sleep (52 ± 11.5% vs. 46.3 ± 10.2%, p = .024) and less REM slee...