Association of Accelerometry‐Measured Physical Activity and Cardiovascular Events in Mobility‐Limited Older Adults: The LIFE (Lifestyle Interventions and Independence for Elders) Study

作者：Shannon K. Cochrane, Shyh‐Huei Chen, Jodi D. Fitzgerald, John A. Dodson, Roger A. Fielding, Abby C. King, Mary McGrae McDermott, Todd Matthew Manini, Anthony P. Marsh, Anne B. Newman, Marco Pahor, Catrine Tudor‐Locke, Walter T. Ambrosius, Thomas W. Buford, Mark Andrew Espeland, William B. Applegate, Daniel P. Beavers, Robert P. Byington, Delilah R. Cook, Curt Daniel Furberg, Lea N. Harvin, Leora F. Henkin, John P Hepler, Fang‐Chi Hsu, Laura Lovato, Wesley Roberson, Julia Rushing, Scott Rushing, Cynthia L. Stowe, Michael P. Walkup, Don G. Hire, W. Jack Rejeski, Jeffrey A. Katula, Peter H. Brubaker, Shannon L. Mihalko, Janine M. Jennings, June J Pierce, Sergei Romashkan, Kushang V. Patel, Denise E. Bonds, Bonnie J. Spring, Joshua Hauser, Diana R. Kerwin, Kathryn J. Domanchuk, Rex Graff, Alvito Rego, Steven N. Blair, Valerie H. Myers, Ron Monce, Nathan E. Britt, Melissa Nauta Harris, Ami Parks McGucken, Ruben Q. Rodarte, Heidi K. Millet, Ben P. Butitta, Sheletta G. Donatto, Shannon H. Cocreham, Cynthia M. Castro, William L. Haskell, Randall Scott Stafford, Leslie A. Pruitt, Kathy A. Berra, Veronica A. Yank, Stephen Douglas Anton, Susan Nayfield, Michael Marsiske, Bhanuprasad D. Sandesara, Jeffrey D. Knaggs, Megan S. Lorow, William C. Marena, Irina Korytov, Holly L. Morris, Margo Fitch, Floris F. Singletary, Jackie Causer, Katie A. Radcliff, Stephanie A. Studenski, Bret H. Goodpaster, Nancy W. Glynn, Oscar Lopez, Neelesh K. Nadkarni, Kathy A. Williams, Mark A. Newman, George Grove, Janet T. Bonk, Jennifer Rush, Piera Kost, Diane G. Ives, Tina E. Brinkley, Jamehl S. Demons, Kaycee M. Sink, Kimberly Kennedy, Rachel Shertzer‐Skinner, Abbie P. Wrights, Rose Fries, Deborah Barr, Robert S. Axtell, Susan S. Kashaf, Nathalie de Rekeneire, Joanne M. McGloin, Karen C. Wu, Denise M. Shepard, Barbara Fennelly, Lynne P. Iannone, Raeleen Mautner, Theresa Sweeney Barnett, Sean N. Halpin, Matthew J. Brennan, Julie A. Bugaj, Maria Zenoni, Bridget M Mignosa, Kaycee M. Sink, Hugh C. Hendrie, Stephen R. Rapp, Joe Verghese, Nancy Woolard, Mark Andrew Espeland, Janine Jennings, Valerie K. Wilson, Eileen Handberg, Gail M. Flynn, Thomas M. Gill, John Hankinson, Carlos A. Vaz Fragoso, Robert M. Kaplan · 发表于：Journal of the American Heart Association · 年份：2017 · DOI：10.1161/jaha.117.007215 · 被引用次数：59 · 研究领域：Physical Activity and Health、Frailty in Older Adults、Nutrition and Health in Aging

Background Data are sparse regarding the value of physical activity ( PA ) surveillance among older adults—particularly among those with mobility limitations. The objective of this study was to examine longitudinal associations between objectively measured daily PA and the incidence of cardiovascular events among older adults in the LIFE (Lifestyle Interventions and Independence for Elders) study. Methods and Results Cardiovascular events were adjudicated based on medical records review, and cardiovascular risk factors were controlled for in the analysis. Home‐based activity data were collected by hip‐worn accelerometers at baseline and at 6, 12, and 24 months postrandomization to either a physical activity or health education intervention. LIFE study participants (n=1590; age 78.9±5.2 [ SD ] years; 67.2% women) at baseline had an 11% lower incidence of experiencing a subsequent cardiovascular event per 500 steps taken per day based on activity data (hazard ratio, 0.89; 95% confidence interval, 0.84–0.96; P =0.001). At baseline, every 30 minutes spent performing activities ≥500 counts per minute (hazard ratio, 0.75; confidence interval, 0.65–0.89 [ P =0.001]) were also associated with a lower incidence of cardiovascular events. Throughout follow‐up (6, 12, and 24 months), both the number of steps per day (per 500 steps; hazard ratio, 0.90, confidence interval, 0.85–0.96 [ P =0.001]) and duration of activity ≥500 counts per minute (per 30 minutes; hazard ratio, 0.76; confidenc...