Impact of 68 Ga-PSMA-11 PET/CT on the Management of Prostate Cancer Patients with Biochemical Recurrence

作者：Jérémie Calais, Wolfgang P. Fendler, Matthias Eiber, J Gartmann, Fang‐I Chu, Nicholas G. Nickols, Robert E. Reiter, Matthew B. Rettig, Leonard S. Marks, Thomas E. Ahlering, Linda My Huynh, Roger Slavik, Pawan Gupta, Andrew Quon, Martin Allen-Auerbach, Johannes Czernin, Ken Herrmann · 发表于：Journal of Nuclear Medicine · 年份：2017 · DOI：10.2967/jnumed.117.202945 · 被引用次数：157 · 研究领域：Prostate Cancer Treatment and Research、Radiopharmaceutical Chemistry and Applications、Cancer, Lipids, and Metabolism

In this prospective survey of referring physicians, we investigated whether and how 68Ga-labeled prostate-specific membrane antigen 11 (68Ga-PSMA-11) PET/CT affects the implemented management of prostate cancer patients with biochemical recurrence (BCR). Methods: We conducted a prospective survey of physicians (NCT02940262) who referred 161 patients with prostate cancer BCR (median prostate-specific antigen value, 1.7 ng/mL; range, 0.05–202 ng/mL). Referring physicians completed one questionnaire before the scan to indicate the treatment plan without 68Ga-PSMA-11 PET/CT information (Q1; n = 101), one immediately after the scan to denote intended management changes (Q2; n = 101), and one 3–6 mo later to document the final implemented management (Q3; n = 56). The implemented management was also obtained via electronic chart review or patient contact (n = 45). Results: A complete documented management strategy (Q1 + Q2 + implemented management) was available for 101 of 161 patients (63%). Seventy-six of these (75%) had a positive 68Ga-PSMA-11 PET/CT result. The implemented management differed from the prescan intended management (Q1) in 54 of 101 patients (53%). The postscan intended management (Q2) differed from the prescan intended management (Q1) in 62 of 101 patients (61%); however, these intended changes were not implemented in 29 of 62 patients (47%). Pelvic nodal and extrapelvic metastatic disease on 68Ga-PSMA-11 PET/CT (PSMA T0N1M0 and PSMA T0N1M1 patterns) was significa...